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Thyroid function and thyroid autoimmunity in patients with type 1 diabetes mellitus.
AbdelRahman Radaideh1, Mohammed El-Khateeb, Anwar M Batieha
1National Center for Diabetes Endocrinology and Genetics Jordan University, Amman, Jordan.
Saudi Medical Journal
|May 20, 2003
Summary
Thyroid dysfunction and autoimmunity are common in type 1 diabetes patients. This study found biochemical thyroid issues and autoimmunity in euthyroid type 1 diabetics, with no significant difference compared to controls.
Area of Science:
- Endocrinology
- Immunology
- Metabolic Disorders
Background:
- Type 1 diabetes mellitus (T1DM) is an autoimmune disease.
- A known association exists between T1DM and autoimmune thyroid disease.
- Investigating thyroid dysfunction and autoimmunity in T1DM patients is crucial.
Purpose of the Study:
- To determine the prevalence of thyroid dysfunction in type 1 diabetic patients.
- To assess the presence of thyroid autoimmunity in type 1 diabetic patients.
- To compare thyroid function and autoimmunity markers between T1DM patients and healthy controls.
Main Methods:
- Seventy-nine type 1 diabetic patients and 127 healthy controls were recruited.
- Thyroid function tests (free thyroxine, free tri-iodothyronine, thyroid stimulating hormone) were performed.
- Thyroid autoantibodies (TPOAb, TgAb) were assessed in a subset of patients.
Main Results:
- Thyroid dysfunction was detected in 8.9% of diabetic patients (4 subclinical hypothyroidism, 3 overt hypothyroidism).
- Subclinical hyperthyroidism was diagnosed in 4.7% of controls.
- Thyroid autoantibodies were present in 9.2% of T1DM patients and 6.3% of controls (P=0.68).
Conclusions:
- Biochemical thyroid dysfunction and thyroid autoimmunity are present in type 1 diabetic patients.
- These findings were observed even in apparently euthyroid individuals.
- No significant difference in thyroid autoimmunity was found between type 1 diabetics and controls.