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Identifying and validating causal genetic alterations in human breast cancer

Stephen P Ethier1

  • 1Department of Radiation Oncology, Division of Radiation and Cancer Biology, The University of Michigan Health System, and the University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109-0982, USA. spethier@umich.edu

Breast Cancer Research and Treatment
|May 21, 2003
PubMed
Summary

Gene amplification drives proto-oncogene activation in human cancers, leading to overexpression. Understanding complex genetic alterations in breast cancer is crucial for developing targeted therapies.

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