Jove
Visualize
Contact Us

Related Experiment Videos

Reducing sample sizes when comparing experimental and control groups.

R H Browne

    Archives of Environmental Health
    |May 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mechanical evaluation of a tapered thread-run-out half-pin designed for external skeletal fixation in small animals.

    Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2011
    Same author

    Mutations responsible for Larsen syndrome cluster in the FLNB protein.

    Journal of medical genetics·2006
    Same author

    Adolescents undergoing surgery for idiopathic scoliosis: how physical and psychological characteristics relate to patient satisfaction with the cosmetic result.

    Spine·2001
    Same author

    The sinister side of PA supply and demand.

    JAAPA : official journal of the American Academy of Physician Assistants·2001
    Same author

    Treatment of femoral fractures in children by pediatric orthopedists: results of a 1998 survey.

    Journal of pediatric orthopedics·2001
    Same author

    The Littler line method and the area under a Gaussian curve: a new method of assessing digital range of motion.

    The Journal of hand surgery·2001
    Same journal

    Exposure of a Cree population living near mine tailings in northern Quebec (Canada) to metals and metalloids.

    Archives of environmental health·2006
    Same journal

    Relationship between health status and psychological distress among the inhabitants in a methylmercury-polluted area in Japan.

    Archives of environmental health·2006
    Same journal

    Medical assessment of the health effects of short leisure trips.

    Archives of environmental health·2006
    Same journal

    Association between exposure to cadmium and blood pressure in Japanese peoples.

    Archives of environmental health·2006
    Same journal

    Development and reduction of hypertension and oxidative stress among detergent industry workers.

    Archives of environmental health·2006
    Same journal

    Evaluation of residential exposure to intermediate frequency magnetic fields.

    Archives of environmental health·2006
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Using historical controls in research can significantly reduce sample sizes for statistical tests. Comparing historical and experimental controls further halves the required sample size for significance testing, improving efficiency.

    Area of Science:

    • Biostatistics
    • Clinical Trial Design
    • Statistical Methods

    Background:

    • Traditional research designs often require large sample sizes for statistical significance.
    • Historical controls offer a potential method to reduce the number of participants needed.
    • Ensuring comparability between historical and experimental groups is crucial for valid results.

    Purpose of the Study:

    • To evaluate the sample size reduction benefits of using historical controls.
    • To assess the impact of testing for equality between historical and experimental controls.
    • To demonstrate the applicability of these methods to rate comparisons and mean comparisons.

    Main Methods:

    • Comparative analysis of sample size requirements for significance testing.

    Related Experiment Videos

  • Statistical testing for equality between historical and experimental control groups.
  • Application of methods to the comparison of rates and means.

    • Main Results:

    • Utilizing a historical control can reduce the required sample size to one-fourth compared to non-historical controls.
    • Demonstrating the equality of historical and experimental controls halves the sample size needed for significance testing.
    • These sample size reductions are applicable to both rate comparisons and mean comparisons.

    Conclusions:

    • Historical controls offer a powerful strategy for reducing sample sizes in comparative studies.
    • Verifying the comparability of controls through statistical testing further enhances sample size efficiency.
    • These methods provide significant advantages in resource optimization for clinical and experimental research.