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Updated: Sep 26, 2026

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
The building block approach to unusual alpha-amino acid derivatives and peptides
1Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India. srk@chem.iitb.ac.in
Abstract:
The building block approach was identified as a useful alternative to the commonly used Bücherer-Berg method for the preparation of cyclic unusual alpha-amino acid derivatives. The symmetrical building blocks were prepared by dialkylation of ethyl isocyanoacetate under solid-liquid phase transfer catalysis conditions while the unsymmetrical building blocks were prepared by a stepwise alkylation of the O'Donnell Schiff base. Metathesis reactions, Suzuki couplings, and cycloaddition reactions were utilized to assemble the building blocks.
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