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Levels of serum vascular cell adhesion molecule-1 in measles

Kenji Ohnishi1, Yasuyuki Kato

  • 1Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Sumida City, Tokyo, Japan. snow-crystal@mri.biglobe.ne.jp

The Southeast Asian Journal of Tropical Medicine and Public Health
|May 22, 2003
PubMed

Insights

Serum vascular cell adhesion molecule-1 (VCAM-1) levels are higher during the acute phase of measles and decrease as patients recover. Measuring VCAM-1 may help assess measles convalescence.

Area of Science:

  • Immunology
  • Virology
  • Clinical Medicine

Background:

  • Serum vascular cell adhesion molecule-1 (VCAM-1) is implicated in various diseases.
  • VCAM-1 levels have not been previously studied in measles patients.

Purpose of the Study:

  • To investigate serum VCAM-1 levels in measles patients during acute and convalescent phases.
  • To assess the potential utility of VCAM-1 as a marker for measles convalescence.

Main Methods:

  • Serum VCAM-1 and creatinine levels were measured in six Japanese measles patients.
  • Measurements were taken during both the acute febrile phase and the defervescent afebrile phase.

Main Results:

  • Serum VCAM-1 levels were significantly higher during the acute febrile phase compared to the convalescent afebrile phase.
  • No significant difference in serum creatinine levels was observed between the two phases.
  • A decrease in serum VCAM-1 was noted as patients moved from the febrile to the afebrile convalescent phase.

Conclusions:

  • Elevated serum VCAM-1 levels during the acute phase of measles decrease during convalescence.
  • Circulating VCAM-1 measurement may serve as a useful indicator for assessing measles recovery.

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