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Related Experiment Video

Updated: May 21, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

[Cerebral Malaria].

Kenji Ohnishi¹

¹Department of Emergency Medical Science, Faculty of Health Science, Suzuka University of Medical Science.

Brain and Nerve = Shinkei Kenkyu No Shinpo

|May 19, 2026

Summary

Cerebral malaria, a severe malaria complication affecting consciousness, occurs when infected red blood cells block brain vessels, not by direct neuron infection. Prompt intravenous artesunate treatment is crucial for suspected cases.

Area of Science:

Neuroscience
Infectious Diseases
Pathophysiology

Background:

Malaria can cause impaired consciousness, indicating cerebral malaria.
Malaria parasites infect red blood cells but not neurons directly.
The exact pathophysiology of cerebral malaria involves microvascular obstruction.

Purpose of the Study:

To clarify the pathophysiology of cerebral malaria.
To highlight the importance of early diagnosis and treatment.

Main Methods:

Review of existing literature on cerebral malaria pathophysiology.
Analysis of clinical presentations and outcomes.

Main Results:

Cerebral malaria is characterized by the adherence of infected red blood cells to cerebral endothelium.

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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Published on: January 3, 2012

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Last Updated: May 21, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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Published on: June 8, 2017

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice

Published on: January 2, 2013

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

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This adherence leads to microvascular obstruction and impaired brain function.

Neuron infection is not the primary mechanism.

Conclusions:

Cerebral malaria pathophysiology involves vascular obstruction, not direct neuronal damage.
Early recognition and prompt intravenous artesunate administration are critical for patient outcomes.