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Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences
Aleksandar K Stanic1, Jang-June Park, Sebastian Joyce
1Department of Microbiology and Immunology, Vanderbilt University School of Medical School, Nashville, TN 37232, USA.
Abstract:
This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T (iNKT) cells and how CD1d and iNKT cells interact to jump-start the immune system. It is postulated that the CD1d-iNKT cell system functions as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates iNKT cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jump-start the immune system.