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Abstract:
Pathohistological changes in the brain of 15 fetuses and newborns caused by intrauterine damage with mouldy fungi, identified according to their morphological characteristics as aspergillas, are described. The predominant localization of the mycotic foci was the periventricular zone of the lateral ventricles. Special attention is given to grave lesions of the brain's vessels and the ependyma of the lateral ventricles. A collation of pathomorphological data with the results of clinical examination of the mothers and children was carried out.
Insights
Intrauterine exposure to mouldy fungi, specifically Aspergillus, caused significant brain damage in fetuses and newborns. Lesions predominantly affected the periventricular zone, brain vessels, and ventricular ependyma.
Area of Science:
- Neuropathology
- Mycology
- Fetal and Neonatal Medicine
Context:
- Intrauterine infections pose a significant threat to fetal and neonatal development.
- Mouldy fungi, particularly Aspergillus species, are increasingly recognized as potential opportunistic pathogens in vulnerable populations.
- Understanding the specific pathohistological manifestations of fungal infections in the developing brain is crucial for diagnosis and management.
Purpose:
- To describe the pathohistological brain changes in fetuses and newborns resulting from intrauterine Aspergillus infection.
- To identify the predominant sites of fungal lesions within the brain.
- To correlate neuropathological findings with maternal and neonatal clinical data.
Summary:
- This study details the brain pathology in 15 fetuses and newborns with intrauterine damage caused by Aspergillus species.
- The periventricular zone of the lateral ventricles was the most common site for mycotic foci.
- Severe lesions of cerebral vessels and the ependyma of the lateral ventricles were observed, alongside a correlation with clinical findings.
Impact:
- Provides critical neuropathological insights into Aspergillus-related fetal and neonatal brain injury.
- Highlights the vulnerability of the periventricular zone and cerebral vasculature to intrauterine fungal infections.
- Informs clinical management strategies and emphasizes the importance of considering fungal etiologies in cases of intrauterine brain damage.