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Cytoskeletons in prokaryotes.

F Mayer1

  • 1Division of Structural Microbiology, Institute for Microbiology and Genetics, Georg August University Goettingen, Grisebachstrasse 8, Germany. fmayer@gwdg.de

Cell Biology International
|May 22, 2003
PubMed
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Prokaryotes possess a cytoskeleton, with bacterial elongation factor Tu (EF-Tu) potentially forming intracellular protofilaments and networks. These structures may serve as attachment sites for cellular macromolecules, possibly representing a primary prokaryotic cytoskeleton.

Area of Science:

  • Cell Biology
  • Microbiology
  • Biochemistry

Background:

  • Eukaryotes and prokaryotes possess cytoskeletons.
  • Bacterial cytoskeletons include tubulin-related FtsZ and actin-related MreB/Mbl.
  • Eukaryotic cytoskeleton components may have evolved from prokaryotic precursors.

Purpose of the Study:

  • To investigate the role of bacterial elongation factor Tu (EF-Tu) in prokaryotic cytoskeleton formation.
  • To explore the potential of EF-Tu in forming intracellular structures and interacting with ribosomes.
  • To discuss the implications of EF-Tu's structural role in prokaryotic cells.

Main Methods:

  • Structural studies of EF-Tu.
  • Experimental data on EF-Tu protofilament and network formation.

Related Experiment Videos

  • Observation of EF-Tu complex formation with active ribosomes.

    • Main Results:

    • EF-Tu forms fibrillar structures in vitro.
    • Experimental data suggest intracellular protofilaments and networks of EF-Tu.
    • EF-Tu forms complexes with active ribosomes, attaching to intracellular protofilaments.

    Conclusions:

    • EF-Tu may function as a structural element in a bacterial cytoskeletal web.
    • These EF-Tu protofilament networks could serve as attachment sites for cellular macromolecules.
    • An EF-Tu-containing cytoskeletal web might represent a primary prokaryotic cytoskeleton, predating MreB precursors.