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Does adenotonsillectomy improve growth in children with obstructive adenotonsillar hypertrophy?
E Selimoğlu1, M A Selimoğlu, Z Orbak
1Department of Otolaryngology, Faculty of Medicine, Atatürk University, Erzurum, Turkey. erolselimoglu@hotmail.com
Insights
Obstructive adenotonsillar hypertrophy is linked to poor growth in children. Adenotonsillectomy improved growth, energy intake, and insulin-like growth factor 1 (IGF-1) levels, suggesting a direct association.
Area of Science:
- Pediatric Endocrinology
- Otolaryngology
- Growth and Development
Background:
- Faltering growth in children can be associated with adenotonsillar hypertrophy.
- The underlying pathophysiological mechanisms remain unclear.
- Adenotonsillar hypertrophy may impact nutrient absorption and hormonal regulation crucial for growth.
Purpose of the Study:
- To investigate the relationship between obstructive adenotonsillar hypertrophy and growth parameters in pre-pubertal children.
- To assess changes in energy intake, serum insulin-like growth factor 1 (IGF-1), and insulin-like growth factor binding protein 3 (IGFBP-3) following adenotonsillectomy.
Main Methods:
- A cohort of 29 pre-pubertal children with obstructive adenotonsillar hypertrophy was studied.
- Measurements included weight and height standard deviation scores, energy intake per kilogram, and serum IGF-1 and IGFBP-3 levels.
- These parameters were assessed before and 6 months after adenotonsillectomy.
Main Results:
- Significant increases in weight and height standard deviation scores were observed 6 months post-adenotonsillectomy.
- Energy intake per kilogram and serum IGF-1 levels were also significantly higher after surgery.
- No significant difference was noted in IGFBP-3 levels.
Conclusions:
- Obstructive adenotonsillar hypertrophy is associated with impaired growth in children.
- Adenotonsillectomy can lead to improved growth, increased energy intake, and elevated IGF-1 levels.
- These findings suggest that adenotonsillar hypertrophy negatively impacts growth through mechanisms involving energy balance and IGF-1 signaling.
Abstract:
Faltering growth may be associated with adenotonsillar hypertrophy, but its pathophysiological mechanism is unclear. This study included 29 pre-pubertal children with obstructive adenotonsillar hypertrophy, and aimed to investigate the probable difference in energy intake and serum insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 (IGFBP-3) levels before and 6 months after adenotonsillectomy. Weight and height standard deviation scores, energy intake per kilogram and serum IGF-1 levels were found to be significantly higher 6 months after adenotonsillectomy, indicating that adenotonsillar hypertrophy is associated with poor growth.