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The Comparative Toxicogenomics Database (CTD).

Carolyn J Mattingly1, Glenn T Colby, John N Forrest

  • 1Department of Bioinformatics, Mount Desert Island Biological Laboratory, Salsbury Cove, Maine 04672, USA. cmattin@mdibl.org

Environmental Health Perspectives
|May 23, 2003
PubMed
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The Comparative Toxicogenomics Database (CTD) is a new genomic resource for toxicologic significance. It will offer annotated associations, diverse sequences, analysis tools, and reagents to aid cross-species research.

Area of Science:

  • Genomics
  • Toxicology
  • Bioinformatics

Background:

  • The Mount Desert Island Biological Laboratory is developing the Comparative Toxicogenomics Database (CTD).
  • Existing resources lack comprehensive, cross-species data on toxicologically significant genes and proteins.
  • There is a need for integrated information to understand environmental health impacts.

Purpose of the Study:

  • To introduce the Comparative Toxicogenomics Database (CTD) as a novel community-supported genomic resource.
  • To detail the planned features and scope of CTD for environmental health, molecular biology, and toxicology research.
  • To invite community participation in CTD's development.

Main Methods:

  • Developing a publicly available database integrating gene/protein information with toxic agents.

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  • Focusing on data annotation from aquatic and mammalian organisms.
  • Incorporating nucleotide and protein sequences from diverse species.
  • Providing analysis tools for comparative studies and information on molecular reagents.

    • Main Results:

    • CTD will be the first database to offer annotated associations between genes, proteins, references, and toxic agents across species.
    • The database will include diverse nucleotide and protein sequences.
    • Analysis tools will enable customized comparative studies.
    • Information on molecular reagents will be available to investigators.

    Conclusions:

    • CTD will facilitate cross-species comparisons of toxicologically significant genes and proteins.
    • These comparisons will enhance understanding of molecular evolution, conserved sequences, and variable sensitivity to environmental agents.
    • CTD aims to foster a deeper understanding of environment-human health interactions.