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[Incidence of peritonitis and catheter exit site infection in children undergoing automatic continuous cyclic
Vytautas Baciulis1, Augustina Jankauskiene, Rimante Cerkauskiene
1Children's Clinic, Vilnius University, Vilnius, Lithuania. vytautas_baciulis@yahoo.com
Insights
In children undergoing continuous cyclic peritoneal dialysis, peritonitis and catheter exit site infections are common. Exit site infections significantly increase the risk of developing peritonitis.
Area of Science:
- Pediatric Nephrology
- Infectious Diseases
Background:
- Continuous cyclic peritoneal dialysis (CCPD) is a treatment for pediatric kidney failure.
- Peritonitis and catheter exit site infections (CESI) are significant complications in patients on CCPD.
Purpose of the Study:
- To investigate the clinical features of peritonitis and CESI in children undergoing CCPD.
- To determine the incidence and causative organisms of these infections.
Main Methods:
- A retrospective review of 8 children on CCPD over a mean of 14.9 months.
- Analysis of peritonitis and CESI episodes, including time to onset, incidence, and microbial causes.
Main Results:
- 14 episodes of peritonitis occurred in 4 children (incidence: 1 episode/9 treatment months).
- Gram-negative organisms (Enterococcus spp.) predominated in peritonitis (35.7%), while gram-positive bacteria (Staphylococcus epidermidis) caused most CESI.
- CESI incidence was 1 episode/8 treatment months. Patients with CESI had a 7-fold higher risk of peritonitis. Two patients died, unrelated to peritonitis.
Conclusions:
- Peritonitis and CESI are frequent in pediatric CCPD patients.
- CESI is a significant risk factor for developing peritonitis.
- Antibiotic therapy is generally effective, but catheter replacement may be necessary.
Abstract:
The aim of this study was to find out the clinical aspects of peritonitis and catheter exit site infection in children undergoing continuous cyclic peritoneal dialysis. The incidence of peritonitis and catheter related infections were reviewed in 8 children on continuous cyclic peritoneal dialysis over a mean period of 14.9+/-15.8 months. Peritonitis occurred in 4 children. There were 14 episodes of peritonitis. The mean time from starting dialysis to the first episode of peritonitis was 1.9+/-1.0 months. The incidence of peritonitis was 1 episode in 9 treatment months. Gram-negative organisms (Enterococcus spp.) were responsible for the majority of episodes (35.7%) of peritonitis and gram-positive bacteria mainly caused the catheter exit site infections (Staphylococcus epidermidis). The incidence of catheter exit site infection was one episode in 8 treatment months. Recurrent peritonitis was present in 1 case. Most patients with dialysis-related peritonitis and catheter exit site infection responded to antibiotic therapy. Catheter was replaced in 2 patients. The mortality rate was 2 out of 8 patients but none of the deaths were related to peritonitis. Patients with exit site infection had 7 times higher risk than those without developing peritonitis.
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