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Published on: November 3, 2018
[Diagnostic value and cytomorphologic findings in bone marrow punctures in children with severe deficiency anemia]
Edo Hasanbegović1, Vildan Bijedić, Senada Mehadzić
1Pedijatrijska klinika, Klinicki centar Univerziteta u Sarajevu.
Insights
Bone marrow aspiration is valuable for diagnosing severe anemia in children. This method identified common iron deficiency with dyshematopoiesis and rare leukemias, aiding in accurate diagnosis and prognosis.
Area of Science:
- Pediatric Hematology
- Diagnostic Pathology
Context:
- Severe anemia in children presents diagnostic challenges.
- Bone marrow aspiration is a key diagnostic tool.
Purpose:
- To evaluate the diagnostic and prognostic utility of bone marrow aspiration in pediatric severe deficiency anemia.
Summary:
- Retrospective analysis of 75 children (0-4 years) with severe anemia (Hb < 8g/dl).
- Bone marrow findings revealed ferriprivic flora with dyshematopoiesis (62.7%), ferriprivic flora (24%), dimorphic features (9.3%), and megaloblastic anemia (1.3%).
- Crucially, bone marrow aspiration identified two cases of leukemia (ALL/L2 and AML/M2).
Impact:
- Highlights bone marrow aspiration's role in identifying diverse etiologies of severe anemia, including nutritional deficiencies and hematologic malignancies.
- Demonstrates the diagnostic significance of bone marrow morphology in pediatric severe anemia.
- Emphasizes the importance of bone marrow aspiration for early leukemia detection in anemic children.
Aims:
To determine the diagnostic and prognostic value the bone marrow aspiration in children with severe deficiency anaemia.
Patients And Methods:
In this retrospective study we analysed 75 children 0-4 years of age who were diagnosed and treated from severe anaemia (Hb < 8g/dl) at Haematologic outpatient and hospital department of Pediatric Clinic in Sarajevo in period of 01.01.1999. to 31.12.1999.
Results:
We analyzed totally 75 children--37 (49.33%) boys and 38 (50.67%) girls. Morphologic finding of bone marrow aspirate smear showed: features of ferriprive flora in 24% of analyzed patients; dimorphic bone marrow features in 9.3% of patients; feriprivic flora with dyshematopoesis in 62.7% and megaloblasic anaemia features in 1.3% of analyzed patients. In two children we diagnosed leukemias from bone marrow aspirate; one was ALL/L2 and the second was AML/M2 leukemia.
Conclusion:
The most frequent found features of bone marrow aspirate were: feriprivic flora with dyshematopoesis. There was only one case of the megaloblastic bone marrow. But, the finding of dymorphic bone marrow indicated to pluricareny of ethiologic factors for beginning severe nutrititive anaemia. Special value of this paper was discovering of two cases of leukemia by the bone marrow aspirate analysis.
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