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Related Experiment Videos

Ketamine associated psychedelic effects and dependence.

D K Lim1

  • 1Department of Adult Psychiatry Unit 3, Woodbridge Hospital, Singapore 539747. dominic.lim@chmeds.ac.nz

Singapore Medical Journal
|May 24, 2003
PubMed
Summary
This summary is machine-generated.

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Ketamine abuse can cause dose-related psychedelic and psychotic effects, including hallucinations. While psychotic symptoms resolve with treatment, addiction is challenging to overcome.

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Ketamine, a dissociative anesthetic since 1970, has significant psychoactive effects.
  • Non-medical ketamine use is a growing concern globally, including in Singapore.

Observation:

  • This paper details the psychedelic and psychotic effects in two ketamine-dependent patients.
  • Observed effects were dose-dependent, including multimodal hallucinations, altered time perception, paranoia, and sensory enhancement.

Findings:

  • Psychotic symptoms in patients resolved rapidly with targeted treatment.
  • Addressing ketamine addiction proved more challenging than managing acute psychotic symptoms.

Implications:

  • Ketamine's effects are linked to its complex actions on N-methyl-D-aspartate (NMDA) receptors.

Related Experiment Videos

  • Clinicians should suspect ketamine abuse in patients presenting with acute multimodal hallucinations and psychosis.