Related Experiment Videos
Selective domino ring-closing metathesis-cross-metathesis reactions between enynes and electron-deficient alkenes
Frédérique Royer1, Claire Vilain, Laurent Elkaïm
1Laboratoire Chimie et Procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France.
Organic Letters
|May 24, 2003
Abstract:
[reaction: see text] A selective domino ring-closing metathesis (RCM)-cross-metathesis (CM) process between enynes and electron-deficient alkenes is reported. The conditions have been optimized for enynes 3 and methyl acrylate with catalyst IV. The scope and limitations of this reaction are described, and a possible mechanism is discussed.