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Related Concept Videos

What are Lipids?

What are Lipids?

Membrane Lipids

Membrane Lipids

Lipids are an essential component of all biological membranes. The average lipid content in mammalian membranes is 50%, though it can be as low as 20% in the inner mitochondrial membrane or as high as 80% in the myelin sheath present around the nerve cells.
Phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin are the most common phospholipids present in mammalian membranes. At physiological pH, phosphatidylserine is negatively charged, while the other three...

Asymmetric Lipid Bilayer

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...

Lipids as Anchors

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...

Overview of Fatty Acid Metabolism

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...

What are Lipids?

What are Lipids?

Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms. The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and carbon-hydrogen bonds...

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[A comparative study of sphingolipids in transplanted melanomas with high and low metastatic activity].

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[The changes in the sphingenine/sphinganine ratio in sphingolipids of transplantable rat tumors depends on a transplantation organ].

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Related Experiment Video

Updated: Jul 6, 2026

Fatty Acid 13C Isotopologue Profiling Provides Insight into Trophic Carbon Transfer and Lipid Metabolism of Invertebrate Consumers

Fatty Acid ¹³C Isotopologue Profiling Provides Insight into Trophic Carbon Transfer and Lipid Metabolism of Invertebrate Consumers

Published on: April 17, 2018

[Positional distribution of fatty acids in the phospholipids of regenerating rat liver].

E V Diatlovitskaia, L I Eĭnisman, S P Mamontov

Biokhimiia (Moscow, Russia)

|March 1, 1976

Summary

During liver regeneration in rats, key fatty acids in lecithins and phosphatidylethanolamines shift, with arachidonic acid decreasing and linoleic acid increasing. This change is most pronounced during mitosis, while cardiolipin composition remains stable.

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Last Updated: Jul 6, 2026

Fatty Acid 13C Isotopologue Profiling Provides Insight into Trophic Carbon Transfer and Lipid Metabolism of Invertebrate Consumers

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Published on: April 17, 2018

Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells

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In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease

Published on: July 19, 2024

Area of Science:

Biochemistry
Cell Biology
Hepatology

Context:

Investigates molecular changes during liver regeneration following partial hepatectomy in rats.
Focuses on the dynamic alterations in glycerophospholipid fatty acid profiles during cellular proliferation.
Examines the specific lipid fractions, namely lecithins and phosphatidylethanolamines, and their fatty acid composition.

Purpose:

To elucidate the changes in fatty acid composition and positioning within glycerophospholipids during rat liver regeneration.
To determine the temporal dynamics of these lipid alterations in relation to the cell cycle, specifically mitosis.
To assess whether the specific fatty acid positioning, characteristic of normal liver, is maintained during regeneration.

Summary:

Regenerating rat liver exhibits altered fatty acid profiles in lecithins and phosphatidylethanolamines, with reduced arachidonic acid and increased linoleic acid compared to normal liver.
These compositional shifts are most significant at 24 hours post-hepatectomy, coinciding with the onset of mitosis.
Despite changes in overall composition, the specific positional distribution of fatty acids in these phospholipids remains consistent with normal liver tissue.
The fatty acid composition of cardiolipin remains unchanged throughout the liver regeneration process.

Impact:

Provides insights into the metabolic adaptations of liver cells during regeneration at a molecular lipid level.
Highlights the differential regulation of fatty acid metabolism in specific phospholipid classes during tissue repair.
Contributes to understanding the maintenance of membrane structure and function during rapid cell division in the liver.