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Yeasts in apical periodontitis.

T M T Waltimo1, B H Sen, J H Meurman

  • 1Institute of Dentistry, University of Turku, Finland. tuomas.waltimo@utu.fi

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|May 24, 2003
PubMed
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Yeasts, primarily Candida albicans, are found in 5-20% of root canal infections and contribute to persistent apical periodontitis. Resistance to calcium hydroxide necessitates exploring alternative antimicrobial treatments for better outcomes.

Area of Science:

  • Microbiology
  • Endodontics
  • Mycology

Background:

  • Yeasts are isolated from 5-20% of apical periodontitis cases, often as Candida albicans.
  • Candida albicans possesses virulence factors that can infect the dentin-pulp complex and cause inflammation.
  • Yeasts are linked to persistent root canal infections resistant to standard treatments.

Purpose of the Study:

  • To investigate the role of yeasts, particularly Candida albicans, in apical periodontitis.
  • To understand the challenges in treating persistent root canal infections involving yeasts.
  • To highlight the need for alternative therapeutic strategies.

Main Methods:

  • Microbiological analysis of infected root canals.
  • Phenotypic and genotypic characterization of Candida albicans isolates.

Related Experiment Videos

  • Review of treatment outcomes for persistent root canal infections.

    • Main Results:

    • Candida species, predominantly C. albicans, are frequently isolated from root canal infections.
    • C. albicans exhibits virulence factors contributing to infection and inflammation.
    • Oral Candida species show resistance to calcium hydroxide, a common medicament.
    • Persistent infections are associated with yeast presence and poor response to therapy.

    Conclusions:

    • Candida albicans plays a pathogenic role in apical periodontitis, especially in persistent cases.
    • The resistance of Candida to calcium hydroxide complicates treatment.
    • Alternative antimicrobial agents are needed to improve the management of yeast-associated apical periodontitis.