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Nitric oxide-mediated cortical activation: a diffuse wake-up system.

Jorge Mariño1, Javier Cudeiro

  • 1Neuroscience and Motor Control Group (NEUROcom), Department Medicina and Instituto Nacional Educacion Fisica Galicia, 15006A Coruña, Spain.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 24, 2003
PubMed
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Nitric oxide (NO) plays a key role in regulating sleep-wake cycles. Inhibiting nitric oxide synthase (NOS) impaired the basal forebrain

Area of Science:

  • Neuroscience
  • Sleep Research
  • Neurochemistry

Background:

  • Nitric oxide (NO) is involved in regulating the sleep-wake cycle.
  • Cholinergic basal forebrain (BF) cells project to the cortex and are implicated in arousal.
  • Nitric oxide synthase (NOS) is present in BF cells, suggesting a role for NO in BF-induced activation.

Purpose of the Study:

  • To investigate the role of NO in the ability of BF cholinergic fibers to induce cortical activation during arousal.
  • To test the hypothesis that NOS inhibition would decrease BF-induced cortical activation.

Main Methods:

  • Experiments were conducted on anesthetized cats.
  • BF stimulation was used to evoke EEG patterns.
  • Nitric oxide synthase (NOS) activity was blocked systemically.

Related Experiment Videos

  • Voltammetric measurements were used to assess cortical NO levels.

    • Main Results:

    • BF stimulation normally evoked an awake-like EEG pattern.
    • Blocking NOS activity significantly impaired the capacity of BF stimulation to induce cortical activation.
    • BF stimulation increased cortical NO levels, an effect blocked by NOS inhibition.

    Conclusions:

    • NO is crucial for the BF-cholinergic system's ability to induce cortical activation.
    • NO plays a significant role in arousal mechanisms.
    • Inhibition of NOS activity reduces the EEG changes associated with BF stimulation.