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Updated: Sep 25, 2026
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
[Study on the association between squamous cell carcinoma of larynx and HPV subgene by PCR]
1Department of Otorhinolaryngology, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510630.
Objective:
To measure the human papilloma virus(HPV) HPV-E1 in squamous cell carcinoma of larynx.
Methods:
Polymerase chain reaction(PCR) was used to detect the HPV subgene in 25 specimens of laryngeal carcinoma and 6 normal larynges.
Results:
Positive expression of HPV-E1 was detected in 17 of 25 cases(68%) with squamous cell carcinoma and all the recurrent cases. However, there was no positive expression of HPV-E1 in the normal larynges (P < 0.01). The expression rate was not significantly different among the histological grad groups.
Conclusion:
HPV-E1 infection was found in laryngeal carcinoma but not related to its histologic grading.
