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Updated: Aug 9, 2026
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
[Hormonal therapy in metastatic prostatic cancer]
Alain Ruffion1, Eric Fontaine, Frédéric Staerman
1Service d'Urologie, Hôpital Henry Gabrielle, Route de Vourles, 69565 Saint Genis Laval. alain.ruffion@chu-lyon.fr
Summary
Androgen deprivation therapy for advanced prostate cancer has evolved with new treatments like Gn-RH agonists and antagonists. This review compares options to optimize quality of life and survival for metastatic patients.
Area of Science:
- Oncology
- Endocrinology
- Urology
Context:
- Advanced prostate cancer treatment relies on androgen deprivation for over 60 years.
- Treatment regimens remain controversial despite advancements.
- Newer therapies include Gn-RH agonists, antagonists, and non-steroidal antiandrogens.
Purpose:
- To review and compare various androgen deprivation therapy options for advanced prostate cancer.
- To evaluate the efficacy of different endocrine therapy modalities.
- To assess the impact of these treatments on patient quality of life and survival.
Summary:
- The article discusses the evolution of androgen deprivation therapies, including LH-RH analogues, non-steroidal antiandrogens, LH-RH antagonists, and Gn-RH agonists.
- It examines different endocrine therapy approaches such as early/late, total/intermittent, and targeted therapy.
- The review analyzes the benefits of each treatment option for metastatic prostate cancer patients.
Impact:
- Provides a comparative overview of advanced prostate cancer treatment strategies.
- Aids clinicians in selecting optimal endocrine therapy based on patient outcomes.
- Informs treatment decisions regarding quality of life and survival in metastatic prostate cancer.
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