Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Topically applied minocycline microspheres: why it works.

John W Dean1, Grishondra L Branch-Mays, Thomas C Hart

  • 1Department of Periodontology, University of Connecticut Health Center, School of Dental Medicine, Farmington, Connecticut, USA.

Compendium of Continuing Education in Dentistry (Jamesburg, N.J. : 1995)
|May 29, 2003
PubMed
Summary

This study found that topical minocycline hydrochloride microspheres, combined with scaling and root planing, effectively treated chronic periodontitis. The treatment demonstrated long-term safety and efficacy in reducing pocket depth and bleeding in patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

3D-Printed Microfluidic Platform for Creating Porous Nanofibrous Microspheres to Regulate Cell Response and Enhance Tissue Regeneration.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

The value of education, training and experience to improve the accuracy of identification: a commentary on 'Inter- and intra-observer variation in phytolith morphometry'.

Annals of botany·2024
Same author

The Development of Thermoresponsive Polymeric Simvastatin Prodrug for the Treatment of Experimental Periodontitis in Rats.

Molecular pharmaceutics·2023
Same author

Effect of interproximal home oral hygiene on clinical parameters and inflammatory biomarkers in patients receiving periodontal maintenance.

Journal of periodontology·2023
Same author

Local simvastatin and inflammation during periodontal mini-flap wound healing: Exploratory results.

Journal of periodontology·2022
Same author

Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: A randomized clinical trial.

Journal of periodontology·2022

Area of Science:

  • Periodontology
  • Clinical Pharmacology
  • Drug Delivery Systems

Background:

  • Chronic periodontitis is a prevalent inflammatory condition affecting periodontal tissues.
  • Scaling and root planing (SRP) is a standard non-surgical periodontal therapy.
  • Adjunctive therapies are explored to enhance SRP outcomes.

Purpose of the Study:

  • To evaluate the long-term safety and efficacy of sustained-release minocycline hydrochloride (HCl) microspheres.
  • To assess minocycline microspheres as an adjunct to SRP in treating chronic periodontitis.

Main Methods:

  • A single-arm, open-label, multicenter clinical trial.
  • 173 patients with moderate-to-severe chronic periodontitis received SRP plus subgingival minocycline microspheres.
  • Minocycline microspheres were applied to pockets ≥ 5 mm at baseline and at 3- and 6-month follow-ups.

Related Experiment Videos

Main Results:

  • Significant improvements in probing pocket depth and reduced bleeding on probing were observed at 1, 3, 6, 9, and 12 months.
  • Minocycline microspheres were well-tolerated, safe, and easy to administer.
  • The adjunctive treatment showed superior results compared to SRP alone.

Conclusions:

  • Sustained-release minocycline microspheres are a safe and effective adjunct to SRP for chronic periodontitis.
  • This therapeutic approach offers improved clinical outcomes in periodontal therapy.
  • Topical minocycline microspheres represent a valuable addition to the management of periodontitis.