Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

BVDV and innate immunity.

Ernst Peterhans1, Thomas W Jungi, Matthias Schweizer

  • 1Institute of Veterinary Virology, University of Bern, Laenggass-Strasse 122, PO Box, CH-3001 Bern, Switzerland. ernst.peterhans@ivv.unibe.ch

Biologicals : Journal of the International Association of Biological Standardization
|May 29, 2003
PubMed
Summary

Bovine viral diarrhea virus (BVDV) infections in cattle can be transient or persistent. Non-cytopathic BVDV evades the innate immune system by suppressing interferon production, enabling persistent infections and immune tolerance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GFP-Tagged E<sup>rns</sup> in Bungowannah Pestivirus: A Tool for Viral Tracking and Functional Studies.

Viruses·2026
Same author

The Pestivirus RNase E<sup>rns</sup> Tames the Interferon Response of the Respiratory Epithelium.

Viruses·2025
Same author

Ergonomic RFID tag placement on surgical instruments - a preliminary user study.

Biomedizinische Technik. Biomedical engineering·2024
Same author

Fifty Shades of E<sup>rns</sup>: Innate Immune Evasion by the Viral Endonucleases of All Pestivirus Species.

Viruses·2022
Same author

Editorial: Global Control and Eradication Programmes for Cattle Diseases.

Frontiers in veterinary science·2021
Same author

Use of multivariate analysis to evaluate antigenic relationships between US BVDV vaccine strains and non-US genetically divergent isolates.

Journal of virological methods·2021

Area of Science:

  • Veterinary Virology
  • Immunology
  • Infectious Diseases

Background:

  • Bovine viral diarrhea virus (BVDV) is a widespread cattle pathogen with cytopathic and non-cytopathic biotypes.
  • BVDV infections manifest as transient or persistent, differing in host immune response and characterized by immunotolerance.
  • Persistent infections, established early in embryonic development by non-cytopathic BVDV, are linked to specific viral strain immunotolerance.

Purpose of the Study:

  • To investigate the role of innate immune responses in transient and persistent BVDV infections.
  • To elucidate the mechanisms by which non-cytopathic BVDV may evade host antiviral defenses.

Main Methods:

  • Discussion of the role of innate immunity in BVDV infection dynamics.
  • Analysis of interferon type I induction in bovine macrophages by different BVDV biotypes.

Related Experiment Videos

  • Evaluation of cellular resistance to interferon induction by double-stranded RNA in BVDV-infected cells.

    • Main Results:

    • Both transient and persistent BVDV infections increase susceptibility to secondary infections due to impaired bacterial killing and chemotaxis.
    • Non-cytopathic BVDV fails to induce interferon type I in bovine macrophages, unlike cytopathic biotypes.
    • Cells infected with non-cytopathic BVDV exhibit resistance to interferon induction by double-stranded RNA.

    Conclusions:

    • Non-cytopathic BVDV possesses a mechanism to suppress interferon type I, a critical component of innate antiviral defense.
    • Suppression of interferon signaling by non-cytopathic BVDV is crucial for establishing persistent infection and immune tolerance.
    • Understanding these immune evasion strategies is vital for managing BVDV in cattle populations.