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Withanolides from Withania coagulans.

Atta ur-Rahman1, Dur-e-Shahwar, Aniqa Naz

  • 1H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

Phytochemistry
|May 29, 2003
PubMed
Summary

Researchers isolated two new withanolides from Withania coagulans. Spectroscopic analysis confirmed the structures of these compounds, expanding knowledge of this plant

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Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Medicinal Plant Research

Background:

  • Withania coagulans is a plant with a history of traditional medicinal use.
  • Withanolides are a class of steroidal lactones found in plants of the Solanaceae family, known for diverse biological activities.

Purpose of the Study:

  • To isolate and characterize novel withanolide compounds from Withania coagulans.
  • To elucidate the chemical structures of the isolated compounds using spectroscopic methods.

Main Methods:

  • Extraction and isolation of chemical constituents from Withania coagulans.
  • Structure elucidation using advanced spectroscopic techniques, including NMR and Mass Spectrometry.

Main Results:

  • Two new withanolides, 20beta-hydroxy-1-oxo-(22R)-witha-2,5,24-trienolide (1) and withacoagulin (2), were identified.
  • A known withanolide, 17beta-hydroxy-14alpha, 20alpha-epoxy-1-oxo-(22R)-witha-3,5,24-trienolide (3), was also isolated.
  • The structures of all three compounds were definitively determined through comprehensive spectroscopic data analysis.

Conclusions:

  • The study successfully identified and characterized new withanolide compounds from Withania coagulans.
  • These findings contribute to the phytochemical understanding of Withania coagulans and the broader class of withanolides.

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