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Absence of linkage between the interleukin-6 gene (-174 G/C) polymorphism and migraine
Innocenzo Rainero1, Giuliana Salani, Walter Valfrè
1Neurology III--Headache Center, Department of Neuroscience, University of Torino, Via Cherasco 15-10126, Turin, Italy. irainero@molinette.piemonte.it
Abstract:
To assess the role of interleukin-6 (IL-6) in migraine, we analyzed the -174 G/C IL-6 gene polymorphism in 268 patients with migraine and 305 controls. No significant difference in the distribution of IL-6 genotypes (chi(2)=0.601, P=0.74) and allelic frequencies (chi(2)=0.024, P=0.876) was found. When patients were subdivided into subgroups (migraine with aura, migraine without aura and mixed headaches), IL-6 alleles were similarly distributed. Comparison of the clinical features of the disease with the -174 G/C IL-6 genotypes showed no significant difference. In conclusion, we found no significant association between the -174 G/C IL-6 polymorphism and the occurrence or the clinical features of migraine.