Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Celiac neuropathy.

R L Chin1, H W Sander, T H Brannagan

  • 1Peripheral Neuropathy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10022, USA. RUC9002@med.cornell.edu

Neurology
|May 29, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disease course and symptoms in smoking versus non-smoking patients with Celiac disease.

Acta gastro-enterologica Belgica·2026
Same author

Portable gluten sensors: qualitative assessments by adults and adolescents with coeliac disease.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2020
Same author

The growing global interest in the gluten free diet as reflected by Google searches.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2020
Same author

Early data on long-term efficacy and safety of inotersen in patients with hereditary transthyretin amyloidosis: a 2-year update from the open-label extension of the NEURO-TTR trial.

European journal of neurology·2020
Same author

Phenotypic shift of small intestinal intra-epithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential.

Clinical and experimental immunology·2020
Same author

Diminished quality of life among adolescents with coeliac disease using maladaptive eating behaviours to manage a gluten-free diet: a cross-sectional, mixed-methods study.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2019
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Celiac disease (CD) is frequently linked to sensory neuropathy, even without typical digestive symptoms. This study highlights the importance of considering CD in neuropathy patients.

Area of Science:

  • Neurology
  • Gastroenterology
  • Immunology

Background:

  • Celiac disease (CD) is an autoimmune enteropathy triggered by gluten ingestion.
  • Neurologic complications affect up to 10% of CD patients, primarily ataxia and peripheral neuropathy.
  • The incidence and presentation of CD-associated peripheral neuropathy remain understudied.

Purpose of the Study:

  • To establish the incidence of celiac disease in patients presenting with neuropathy.
  • To delineate the clinical characteristics of celiac disease-associated neuropathy.

Main Methods:

  • Retrospective review of medical records for 20 patients with biopsy-confirmed celiac disease and neuropathy.
  • Analysis of clinical symptoms, electrophysiologic studies, and sural nerve biopsy findings.

Related Experiment Videos

  • Serologic testing for ganglioside antibodies using an agglutination assay.

    • Main Results:

    • Nine patients (45%) presented with neuropathy as the initial or sole manifestation of CD.
    • Sensory symptoms (burning, tingling, numbness, distal loss) were predominant; weakness was rare.
    • Electrophysiologic studies were often normal (90%), while nerve biopsies showed axonopathy; 65% tested positive for ganglioside antibodies.

    Conclusions:

    • Celiac disease is a common cause of sensory neuropathy, particularly when electrophysiologic studies are normal.
    • CD should be suspected in patients with neuropathy, irrespective of gastrointestinal symptoms.
    • Ganglioside antibodies may serve as a potential biomarker for CD-associated neuropathy.