Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Head trauma preceding PD: a case-control study.

J H Bower1, D M Maraganore, B J Peterson

  • 1Department of Neurology, Mayo Foundation, Rochester, MN 55905, USA. bower.james@mayo.edu

Neurology
|May 29, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gaussian process regression for thermal transport analysis in infrared imaging video bolometry.

The Review of scientific instruments·2026
Same author

Host traits and temperature predict biogeographical variation in seagrass disease prevalence.

Proceedings. Biological sciences·2025
Same author

Developing a robust sensor for infrared imaging bolometers.

The Review of scientific instruments·2024
Same author

40-Year Incidence of Early-Onset Parkinson's Disease in Southeast Minnesota.

Journal of Parkinson's disease·2023
Same author

Sensitivity improvement of infrared imaging video bolometer for divertor plasma measurement.

The Review of scientific instruments·2021
Same author

Development of a weighted sum estimate of the total radiated power from large helical device plasma.

The Review of scientific instruments·2021
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Head trauma, especially with loss of consciousness, is linked to a higher risk of developing Parkinson's disease (PD). The severity of the head injury influences the increased risk for PD.

Area of Science:

  • Neurology
  • Epidemiology
  • Trauma Research

Background:

  • Parkinson's disease (PD) is a progressive neurodegenerative disorder.
  • The potential link between head trauma and PD has been a subject of ongoing research.
  • Understanding risk factors for PD is crucial for prevention and early intervention strategies.

Purpose of the Study:

  • To investigate the association between preceding head trauma and the development of Parkinson's disease.
  • To determine if the severity of head trauma influences the risk of developing PD.

Main Methods:

  • A case-control study design was employed.
  • 196 incident Parkinson's disease cases were identified using the Rochester Epidemiology Project medical records-linkage system (1976-1995).
  • Each case was matched by age and sex to a general population control, with medical records reviewed for head trauma history.

Related Experiment Videos

Main Results:

  • A significantly higher frequency of head trauma was observed in Parkinson's disease cases compared to controls (odds ratio [OR] = 4.3).
  • Mild head trauma with amnesia alone did not increase risk, but mild trauma with loss of consciousness or more severe trauma showed a substantially elevated risk (OR = 11.0).
  • Head trauma resulting in hospitalization was more frequent in cases, though not statistically significant (OR = 8.0).

Conclusions:

  • The study suggests a significant association between head trauma and the subsequent development of Parkinson's disease.
  • The risk of PD associated with head trauma appears to be dependent on the severity of the injury.
  • Despite a high odds ratio, the population attributable risk for PD from head trauma is modest due to the event's relative rarity.