Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Recent developments in diisocyanate asthma.

Qing Liu¹, Adam V Wisnewski

¹Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|May 30, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Identification and validation of genes encoding humoral specificity for the chemical allergen toluene diisocyanate.

PloS one·2026

Same author

Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA-1 in Pathologic Responses to Diisocyanate.

Chemical research in toxicology·2024

Same author

Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers: Results of a Longitudinal Cohort.

Journal of occupational and environmental medicine·2023

Same author

Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue: December 2020-August 2021.

Journal of occupational and environmental medicine·2022

Same author

Glutathione reactivity with aliphatic polyisocyanates.

PloS one·2022

Same author

Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses.

PloS one·2022

Same journal

Overlapping Mechanisms and Novel Biomarkers Define Asthma and COPD as a Spectrum of Airway Disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Real-World Variation in Post-Dose Supervision and Activity Restriction During Maintenance Cow's Milk Oral Immunotherapy.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Small Airway Dysfunction and Prior Exacerbations are Common in Primarily Well-Controlled Pediatric Asthma.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Pharmacokinetics and pharmacodynamics of AQST-109 sublingual film in oral allergy syndrome: A phase 2 study.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Biomarkers for COPD with Type 2 Inflammation.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

Same journal

Remission and Meaningful Outcomes in Chronic Rhinitis and Rhinosinusitis.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026

See all related articles

Diisocyanate-induced asthma is a complex condition involving immune responses, genetics, and airway epithelium. Further research is needed to understand its causes and develop diagnostic biomarkers.

Area of Science:

Occupational Medicine
Immunology
Pulmonology

Background:

Diisocyanate asthma shares similarities with allergic asthma but has distinct immune-mediated pathways.
Recent research explores the human immune response to diisocyanates, revealing differences from common atopic asthma.

Purpose of the Study:

To summarize recent experimental findings on diisocyanate asthma.
To discuss the impact of new data on understanding disease pathogenesis and diagnosis.

Main Methods:

Literature review of PubMed articles from 1999-2001.
Inclusion of older references for historical context.
Data grouped to highlight key concepts in diisocyanate asthma pathogenesis.

Main Results:

Related Experiment Videos

Immune responses, airway epithelium, and genetic factors contribute to diisocyanate asthma.
Studies suggest both immune-dependent and antigen-independent mechanisms.
Early removal from exposure is prognostic; diagnostic tests for sensitivity and susceptibility are needed.

Conclusions:

Diisocyanate-induced asthma is multifactorial, involving immune, epithelial, and genetic components.
Further research is crucial to elucidate pathogenesis and identify biomarkers for sensitization and susceptibility.