Cognitive and behavioral disturbances in Parkinson's disease

The dysfunction of the striato frontal circuits that occurs in Parkinson's disease results in cognitive and behavioural problems as well as motor impairment. Depression is frequent and cognitive deficits also occur that progress with advancing illness, sometimes to subcortical dementia. Spread of Lewy bodies to the cortex, cholinergic and monoaminergic neurotransmission deficiency, or concurrent Alzheimer pathology may be the anatomical bases of dementia.