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Hypothalamic digoxin and hemispheric chemical dominance: relation to speech and language dysfunction
Ravi Kumar Kurup1, Parameswara Achutha Kurup
1Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
The International Journal of Neuroscience
|May 31, 2003
Summary
The isoprenoid pathway is overactive in dyslexia and speech disorders, with altered metabolite levels impacting neurotransmission and synaptic function. Right hemispheric dominance may contribute to these speech and developmental challenges.
Area of Science:
- Biochemistry
- Neuroscience
- Genetics
Background:
- The isoprenoid pathway yields critical metabolites like digoxin, dolichol, and ubiquinone.
- Digoxin influences neurotransmitter transport, while dolichols affect synaptic glycoconjugate synthesis.
Purpose of the Study:
- To investigate the isoprenoid pathway's role in dyslexia, global aphasia recovery, and speech developmental delay.
- To explore the influence of hemispheric dominance on speech disorder pathogenesis.
Main Methods:
- Assessed HMG CoA reductase activity, magnesium, digoxin, dolichol, ubiquinone, and tryptophan/tyrosine catabolites.
- Measured RBC (Na+)-K+ ATPase activity, glycoconjugate metabolism, and membrane composition.
Main Results:
- Dyslexia, speech delay, and aphasia showed an upregulated isoprenoid pathway with elevated digoxin and dolichol.
- Decreased RBC (Na+)-K+ ATPase, magnesium, and ubiquinone levels were observed.
- Altered tryptophan/tyrosine catabolites, increased GAGs and glycohydrolases, and changes in RBC membrane composition indicated synaptic dysfunction.
Conclusions:
- The isoprenoid pathway's dysregulation contributes to speech and developmental disorders.
- Right hemispheric chemical dominance may be implicated in the genesis of these conditions.
- Observed metabolic and membrane alterations correlate with synaptic inactivity.