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Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
Published on: October 26, 2009
[Effect of dan-shen, san-qi of different proportion on platelet aggregation and adhesion in normal rabbits]
Ting Liu1, Cai-ling Qin, Yi Zhang
1Institute of Chinese Materia Medica, China Academy of TCM, Beijing 100700, China.
Objective:
To observe the effect of the crude extracts of Dan-shen root and San-qi of different proportion on platelet aggregation and adhesion in normal rabbits.
Method:
With rabbits, ig. (4d, exsanguinated via carotid artery, percentage of platelet aggregation and adhesion was measured.
Result And Conclusion:
Aspirin (4.4 mg/Kg) could markedly inhibit platelet aggregation and adhesion in normal rabbit. The proportions of Dan-shen root/San-qi (10:0, 10:1, 10:3, 10:6, 1:10) could markedly inhibit platelet aggregation, among which 10:3 was the best. San-qi alone had little effect on aggregation. The proportions of Dan-shen root/San-qi (10:3, 10:6, 0:10) could markedly inhibit platelet adhesion, among which 0:10 was the best, and the proportions(10:0, 10:1, 1:10) had little effect.
