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[Application of beta-cyclodextrin inclusion technique in new dosage form of angelica sinensis essential oil]
Chang-xin Zhou1, Jian-kai Zou, Yu Zhao
1Department of Traditional Chinese Medicine and Natural Drugs Research, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, Zhejiang, China. C.X.Zhou@zju.edu.cn
Objective:
To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex.
Method:
GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound.
Result:
The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same.
Conclusion:
The results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.
