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Chronic renal failure in children

S Jamro1, N A Channa, A H Shaikh

  • 1Department of Paediatrics, Chandka Medical College, Larkana.

JPMA. the Journal of the Pakistan Medical Association
|June 5, 2003
PubMed

Insights

This study identified common clinical presentations and causes of chronic renal failure (CRF) in children. Early diagnosis of conditions like reflux nephropathy can prevent progression to end-stage renal disease (ESRD).

Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Clinical Research

Background:

  • Chronic renal failure (CRF) is a significant health concern in pediatric populations.
  • Understanding the clinical presentation and etiological factors of pediatric CRF is crucial for timely intervention.

Purpose of the Study:

  • To investigate the clinical manifestations of chronic renal failure in children.
  • To identify the primary underlying causes of chronic renal failure in the studied pediatric cohort.

Main Methods:

  • A descriptive prospective study was conducted.
  • Data was collected from pediatric patients diagnosed with CRF between January 1993 and December 1996.
  • Two major pediatric healthcare centers in Pakistan were involved.

Main Results:

  • Seventy-eight children with CRF were analyzed, with a male predominance (M:F ratio 1.8:1).
  • Most children (90%) presented after the age of three.
  • Common symptoms included anemia (93.5%), growth retardation (74.3%), urinary complaints (65.3%), and hypertension (53.8%).
  • Key causes identified were reflux nephropathy (24.5%), posterior urethral valves (23%), chronic glomerulonephritis (15.4%), and urolithiasis (14%).

Conclusions:

  • Prompt diagnosis and management of prevalent causes of pediatric CRF are essential.
  • Intervention can potentially prevent or delay the advancement to end-stage renal disease (ESRD).
Abstract

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