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Mucosal immunity.

Lloyd Mayer1

  • 1Department of Medicine and Immunobiology, Mount Sinai School of Medicine, New York, New York, USA.

Pediatrics
|June 5, 2003
PubMed
Summary
This summary is machine-generated.

Food allergies stem from abnormal immune responses to oral antigens. Maturation of the mucosa-associated lymphoid tissue typically resolves food allergies in most children.

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Area of Science:

  • Immunology
  • Gastroenterology
  • Allergy Research

Background:

  • Food allergy involves an abnormal immune response to oral antigens.
  • Normal mucosal immunity typically suppresses immune responses.
  • Immune pathways in newborns are immature, leading to potential sensitization.

Purpose of the Study:

  • To examine normal mucosal immune responses to oral antigens.
  • To identify potential defects in these pathways in food-allergic patients.

Main Methods:

  • Review of normal mucosal immune responses.
  • Postulation of defects in food allergy.

Main Results:

  • Normal mucosal immunity depends on physical barriers, antigen digestion, and T-cell suppression.

Related Experiment Videos

  • Maturation of mucosa-associated lymphoid tissue leads to tolerance and outgrowing allergies.
  • Defects in these pathways may underlie persistent food allergies.

    • Conclusions:

    • Understanding normal mucosal immunity is key to understanding food allergies.
    • Defective immune regulation at the mucosal level is implicated in food allergy pathogenesis.