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Tissue macroarray: a simple and cost-effective method for high-throughput studies
Liang Wang1, Michael T Deavers, Anais Malpica
1Department of Pathology, The University of Texas-Houston Medical School, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Abstract:
The tissue microarray technique is a powerful technique that can examine many clinical specimens in a single slide. However, this technique requires a specialized instrument for the construction of tissue microarray block. The authors describe an alternative tissue macroarray technique for the simultaneous analysis of multiple clinical specimens on a single slide. As an example of this method, the authors assembled 12 tumor samples from 12 different paraffin blocks on a glass slide and then immunostained with hMLH1 antibody. This simple method does not need specialized equipment and should be an alternative efficient approach for large-scale clinical specimens.