Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulsatile flow dynamics maintain pulmonary artery architecture.

JCI insight·2026
Same author

Fibrin defines tissue stiffness and biomechanical signaling in regenerating zebrafish hearts as revealed by high-resolution stiffness mapping.

iScience·2026
Same author

The persistence of potential: The life of Sir John B. Gurdon.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Integration of spatial and single-nucleus transcriptomics to map gene expression in the developing mouse kidney.

Development (Cambridge, England)·2025
Same author

Ureteric stromal progenitors give rise to kidney inner cortical pericytes via an arterial mural cell intermediate.

Developmental biology·2025
Same author

Zonal endothelial cell heterogeneity underlies murine renal vascular development.

Angiogenesis·2025
Same journal

Generalizable AI predicts immunotherapy outcomes across cancers and treatments.

Nature medicine·2026
Same journal

Immune aging biomarkers for clinical trials.

Nature medicine·2026
Same journal

Lassa fever countermeasures gather pace.

Nature medicine·2026
Same journal

Why high scores do not mean application readiness for health AI.

Nature medicine·2026
Same journal

Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial.

Nature medicine·2026
Same journal

Biological aging might help to explain the rising risk of early-onset cancer.

Nature medicine·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Endothelial signaling during development.

Ondine Cleaver1, Douglas A Melton

  • 1Howard Hughes Medical Institute and Department of Cellular and Molecular Biology, Harvard University, 7 Divinity Ave, Cambridge, Massachusetts 02138, USA. ocleaver@fas.harvard.edu

Nature Medicine
|June 5, 2003
PubMed
Summary
This summary is machine-generated.

Blood vessels communicate with surrounding cells through paracrine signaling, influencing development and cell fate. Understanding this signaling offers insights into diseases and potential new therapies.

More Related Videos

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing
09:59

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing

Published on: October 11, 2021

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology
09:12

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology

Published on: July 28, 2023

Related Experiment Videos

Last Updated: May 12, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
04:23

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells

Published on: March 31, 2021

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing
09:59

Isolation of Murine Retinal Endothelial Cells for Next-Generation Sequencing

Published on: October 11, 2021

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology
09:12

In Vitro Model of Fetal Human Vessel On-chip to Study Developmental Mechanobiology

Published on: July 28, 2023

Area of Science:

  • Vascular biology and developmental signaling.

Background:

  • Blood vessels are crucial for metabolic exchange and tissue perfusion.
  • Emerging evidence highlights paracrine signaling between vascular and target organ cells.
  • This signaling plays a role in embryonic development and cell differentiation.

Purpose of the Study:

  • To elucidate the nature and heterogeneity of paracrine signaling from blood vessels.
  • To understand the implications of this signaling in embryonic development and adult tissues.
  • To explore potential therapeutic applications for diseases involving vascular dysfunction.

Main Methods:

  • The study likely involves investigating cell-cell communication pathways.
  • Methods may include genetic analysis, molecular biology techniques, and imaging in developmental models.

Main Results:

  • Detailed findings are not provided in the abstract.
  • The abstract suggests that paracrine signaling from blood vessels is a key developmental mechanism.

Conclusions:

  • Understanding vascular paracrine signaling is vital for developmental biology.
  • This research may pave the way for novel therapeutic strategies for cardiovascular disease, diabetes, and cancer.