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Filament instability and rotational tissue anisotropy: A numerical study using detailed cardiac models
1Department of Physics, University of California, San Diego, La Jolla, California 92093.
Chaos (Woodbury, N.Y.)
|June 5, 2003
Summary
Cardiac tissue anisotropy
Area of Science:
- Computational biology
- Cardiac electrophysiology
Background:
- Cardiac tissue anisotropy influences spiral wave dynamics.
- Vortex filament breakup is critical in cardiac arrhythmias.
Purpose of the Study:
- Investigate the role of cardiac tissue anisotropy in vortex filament breakup.
- Compare the effects in two distinct cardiac models.
Main Methods:
- Utilized the Beeler-Reuter and Luo-Rudy cardiac models.
- Modified models to simulate stable two-dimensional spiral waves.
- Analyzed vortex filament behavior in parallelepipedal tissue slabs.
Main Results:
- Anisotropy destabilized vortex filaments in the Beeler-Reuter model.
- Anisotropy did not destabilize filaments in the Luo-Rudy model.
- Identified model-dependent behavior in filament stability.
Conclusions:
- Cardiac tissue anisotropy's effect on vortex filaments is model-dependent.
- Spiral wave tip trajectories may explain observed model differences.
- Findings contribute to understanding arrhythmia mechanisms.