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Updated: Jul 27, 2026

Cell Co-culture Patterning Using Aqueous Two-phase Systems
Published on: March 26, 2013
Symmetric patterns in linear arrays of coupled cells
Irving R. Epstein1, Martin Golubitsky
1Department of Chemistry and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254-9110Department of Mathematics, University of Houston, Houston, Texas 77204-3476.
Abstract:
In this note we show how to find patterned solutions in linear arrays of coupled cells. The solutions are found by embedding the system in a circular array with twice the number of cells. The individual cells have a unique steady state, so that the patterned solutions represent a discrete analog of Turing structures in continuous media. We then use the symmetry of the circular array (and bifurcation from an invariant equilibrium) to identify symmetric solutions of the circular array that restrict to solutions of the original linear array. We apply these abstract results to a system of coupled Brusselators to prove that patterned solutions exist. In addition, we show, in certain instances, that these patterned solutions can be found by numerical integration and hence are presumably asymptotically stable.
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