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Coagulation and fibrinolytic activity in patients with acute cerebral infarction
Feng Li1, Guibin Zhang, Wenzhou Zhao
1Department of Neurology, People's Hospital, Wuhan University, Wuhan 430060, China. gylfsd@yahoo.com.cn
Insights
Patients with acute cerebral infarction exhibit elevated D-dimer, t-PA, and PAI-1 levels, alongside reduced plasminogen activity. These findings suggest hypercoagulability and secondary hyperfibrinolysis in acute stroke.
Area of Science:
- Neuroscience
- Hematology
- Biochemistry
Background:
- Acute cerebral infarction, or stroke, involves complex hemostatic alterations.
- Understanding the roles of key coagulation and fibrinolysis factors is crucial for diagnosis and treatment.
Purpose of the Study:
- To quantify D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and plasminogen (PLG) activity in plasma and cerebrospinal fluid (CSF) of acute cerebral infarction patients.
- To explore the clinical significance of these markers in acute stroke.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure DD, t-PA, and PAI-1 concentrations in plasma and CSF.
- Chromogenic methods determined PLG biological activity.
- Results were compared between acute cerebral infarction patients and healthy controls.
Main Results:
- Significantly higher concentrations of DD, t-PA, and PAI-1 were observed in both plasma and CSF of patients compared to controls (P < 0.01).
- PLG activity was markedly lower in patients with acute cerebral infarction than in the control group (P < 0.01).
Conclusions:
- Acute cerebral infarction is characterized by a state of hypercoagulability.
- Secondary hyperfibrinolysis is also present in patients experiencing acute cerebral infarction.
Objective:
To measure the concentration of D-dimer (DD), tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen (PLG) activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance.
Methods:
The concentrations of D-dimer, t-PA, and PAI-1 in plasma and cerebrospinal fluid in patients were measured by enzyme-linked immunosorbent assay (ELISA). The PLG biological activity was detected using the chromophore method. The results were compared with those of the controls.
Results:
The concentrations of D-dimer, t-PA and PAI-1 in cerebrospinal fluid and plasma in patients with acute cerebral infarction were much higher than those of normal subjects (P < 0.01). Conversely, the level of PLG activity was significantly lower in the patients than in the controls (P < 0.01).
Conclusion:
Hypercoagulability and secondary hyperfibrinolysis exist in patients with acute cerebral infarction.