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Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors
Stefan Jaroch1, Peter Hölscher, Hartmut Rehwinkel
1Department of Medicinal Chemistry, Research Center Europe, Corporate Research, Schering AG, D-13342-, Berlin, Germany. stefan.jaroch@shering.de
Bioorganic & Medicinal Chemistry Letters
|June 5, 2003
Abstract:
Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.