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Lipopolysaccharide induces biochemical alterations in chicks trained on the passive avoidance learning task
Kerryn M Sell1, Simon F Crowe, Stephen Kent
1School of Psychological Science, La Trobe University, Victoria 3086, Bundoora, Australia.
Physiology & Behavior
|June 5, 2003
Summary
Lipopolysaccharide (LPS) impairs memory processing in young chicks by affecting brain function and stress hormones. This immune system activation also caused sickness behaviors similar to those seen in older chickens.
Area of Science:
- Neuroscience
- Immunology
- Animal Behavior
Background:
- Immune system activation with lipopolysaccharide (LPS) has been shown to impair memory processing in young chicks.
- Understanding the mechanisms behind LPS-induced memory deficits is crucial for cognitive research.
Purpose of the Study:
- To investigate if LPS impairs Na(+)/K(+)-ATPase functioning and increases corticosterone (CORT) concentrations in day-old chicks.
- To determine if LPS induces sickness behaviors in day-old chicks, similar to older chickens.
Main Methods:
- Day-old chicks were trained on a passive avoidance learning task.
- Brain Na(+)/K(+)-ATPase activity and plasma CORT concentrations were measured after LPS administration.
- Body temperature and food intake were monitored to assess sickness behavior.
Main Results:
- LPS administration decreased brain Na(+)/K(+)-ATPase activity.
- LPS increased plasma CORT concentrations in chicks.
- LPS increased body temperature dose-dependently and decreased food intake at the lowest dose tested.
Conclusions:
- The study provides insights into the mechanisms underlying LPS-induced memory deficits, involving impaired Na(+)/K(+)-ATPase function and elevated CORT.
- LPS elicits sickness behaviors in day-old chicks, consistent with findings in older chickens.