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Updated: Aug 14, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
[Changes of relative variables about prethrombosis state and its clinical significance in patients with pregnancy
Bao-ying Liu1, Mei Zhong, Yan-hong Yu
1Department of Obstetrics and Gynecology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Objective:
To explore the changes of the hemorrheology coagulation and fibrinolytic system in patients with pregnancy induced hypertension (PIH).
Methods:
To examine the platelet alphagranule membrane protein (GMP-140), Von-Willebrand factor (vWF), antithrombin III activity (AT-III), plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in 30 non-pregnancy women, 30 normal late pregnancy women and 50 pregnancy induced hypertension women.
Results:
In PIH group vWF [(156 +/- 23)%], GMP-140 [(23.9 +/- 3.6) microg/L], Fbg [(15.5 +/- 0.8) g/L], PLG [(141 +/- 9)%], D-Dimer [(1.42 +/- 0.32) mg/L], PAI [(9.2 +/- 0.8) kU/L] were obviously higher than those of control group. AT-III, ProC in PIH group were lower than that of the control group (P < 0.01). t-PA has no significant differences (P > 0.05).
Conclusions:
Prethrombotic state was shown in normal late pregnancy women. Obvious prethrombotic state was shown in patients with pregnancy induced hypertension women.
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