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Congenital leukaemia in Down Syndrome--a case report
Moatoshi Aier1, Thangura Zadeng, Debdatta Basu
1Department of Pathology, Jawaharlal Institute of Post Graduate Medical Education and Research, Pondicherry.
Indian Journal of Pathology & Microbiology
|June 6, 2003
Abstract:
A 17 days old male infant, who had features of Down Syndrome, presented with fever, refusal to feed and seizures. He had papular, crusted skin lesions, moderate hepatosplenomegaly and a rapid downhill course. Peripheral blood and bone marrow aspirate showed features of acute leukaemia. Congenital Leukaemia is a rare malignancy associated with a very poor prognosis. Paradoxically, many cases of Congenital Leukaemia, especially in infants with Down Syndrome, show spontaneous remission.