Simulation of pore formation in lipid bilayers by mechanical stress and electric fields
D Peter Tieleman1, Hari Leontiadou, Alan E Mark
1Department of Biological Sciences, University of Calgary, Alberta, Canada T2N 1N4. tielman@ucalgary.ca
Abstract:
We describe computer simulations of pore formation and membrane rupture of phospholipid bilayers under mechanical and electrical stress. On the nanosecond simulation time scale, pores are induced by a lateral pressure exceeding -200 bar or by an applied electric field of 0.5 V/nm.
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