Targeted retentive device for oro-dental infections: formulation and development

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Microbiology

Background:

• Oro-dental infections require effective and sustained antibiotic delivery.
• Systemic administration of antibiotics can lead to side effects.
• Controlled-release formulations are needed for localized treatment.

Purpose of the Study:

• To develop and evaluate amoxycillin trihydrate-loaded ethylene vinyl acetate fibers for controlled oro-dental infection treatment.
• To assess the in vitro and in situ release kinetics of amoxycillin from the fibers.
• To determine the antimicrobial efficacy against common oro-dental pathogens.

Main Methods:

• Melt spinning technique was used to fabricate amoxycillin trihydrate-loaded ethylene vinyl acetate fibers.
• In vitro drug release studies were conducted in alkaline borate buffer (pH 8.1) at 37°C and 50 rpm.
• In situ studies simulated periodontal pocket conditions using a continuous flow-through apparatus.
• Microbiological evaluation was performed against Staphylococcus aureus, Streptococcus mutans, and Bacteroides cereus.

Main Results:

• Fibers demonstrated sustained amoxycillin release over 6 days, following Fickian diffusion.
• In situ studies showed drug concentrations exceeding the minimum inhibitory concentration (MIC).
• The formulation exhibited significant antimicrobial activity against tested oro-dental pathogens.
• Stability studies indicated a degradation rate constant of 2.79 x 10(-4) per day.

Conclusions:

• Amoxycillin trihydrate-loaded ethylene vinyl acetate fibers provide effective controlled delivery for oro-dental infections.
• The developed fibers represent a promising alternative to conventional systemic antibiotic therapy.
• The melt-spun fibers offer a feasible approach for localized and sustained antimicrobial treatment.