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The nucleolus: a site of ribonucleoprotein maturation
Susan A Gerbi1, Anton V Borovjagin, Thilo Sascha Lange
1Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Division of Biology and Medicine, JW Wilson Laboratory, 69 Brown Street, Providence, RI 02912, USA. susan_gerbi@brown.edu
Abstract:
The nucleolus is the site of ribosomal RNA synthesis, processing and ribosome maturation. Various small ribonucleoproteins also undergo maturation in the nucleolus, involving RNA modification and RNA-protein assembly. Such steps and other activities of small ribonucleoproteins also take place in Cajal (coiled) bodies. Events of ribosome biogenesis are found solely in the nucleolus, which is the final destination of small nucleolar RNAs after their traffic through Cajal bodies. However, nucleoli are just a stopping point in the intricate cellular traffic for small nuclear RNAs and other ribonucleoproteins.