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Long-term voluntary ethanol drinking increases expression of NMDA receptor 2B subunits in rat frontal cortex
Markus S H Henniger1, Carsten T Wotjak, Sabine M Hölter
1Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, D-80804 Munich, Germany. henninger@mpipsykl.mpg.de
European Journal of Pharmacology
|June 6, 2003
Abstract:
Forced ethanol drinking for several days and application of ethanol to cell cultures changes expression levels of various NMDA receptor subunits in rodents. Therefore, we investigated the influence of long-term voluntary ethanol consumption on the expression of NMDA receptor 2B (NR2B) subunits in several forebrain regions of rats [corrected]. This result is in accordance with and extends findings from studies using high doses of ethanol for a short period and suggests that the NR2B might be a potential target for an effective treatment of alcoholic patients.