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Assessment of Gastric Emptying in Non-obese Diabetic Mice Using a [13C]-octanoic Acid Breath Test
Published on: March 23, 2013
The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in mice
Erin Symonds1, Ross Butler, Taher Omari
1Centre for Paediatric Gastroenterology and Adolescent Gastroenterology, Women's and Children's Hospital, North Adelaide, and Department of Physiology, University of Adelaide, South Australia, Australia. erinsymonds@yahoo.com
Abstract:
The effect of the GABA(B) receptor agonist baclofen, a potential treatment for gastroesophageal reflux, on gastric emptying has not been determined. The effect of 1-4 mg/kg baclofen on liquid and solid gastric emptying in mice was evaluated by noninvasive [13C] breath tests. Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying.
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