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Gastric emptying and myoelectrical activity testing in children with esophageal atresia: A pilot study

Carlijn Mussies1, Gilles Duvoisin2,3, Angela Le4

  • 1Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC University of Amsterdam Amsterdam the Netherlands.

JPGN Reports
|March 28, 2024
PubMed

Insights

Gastric function tests revealed abnormalities in 80% of children with esophageal atresia (EA). However, these gastric function abnormalities did not correlate with their reported quality of life.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Disorders
  • Congenital Anomalies

Background:

  • Esophageal atresia (EA) can lead to gastrointestinal issues and reduced quality of life (QOL) in children.
  • Assessing gastric function is crucial for understanding these complications.

Purpose of the Study:

  • To evaluate the feasibility and clinical utility of gastric function testing in children with EA.
  • To correlate gastric function test results with gastrointestinal symptoms and QOL.

Main Methods:

  • Utilized the PedsQL Gastrointestinal Symptoms Questionnaire (PedsQL-GI) for symptom and QOL assessment.
  • Employed 13C-gastric emptying octanoic acid breath test (13C-GEBT) for gastric emptying.
  • Used surface electrogastrography (EGG) to study gastric myoelectrical activity.

Main Results:

  • Abnormalities in gastric function tests (13C-GEBT and/or EGG) were found in 80% of the 15 pediatric patients.
  • Abnormal slow waves on EGG were associated with a higher incidence of abnormal gastric emptying.
  • No significant correlation was observed between 13C-GEBT or EGG findings and PedsQL-GI scores.

Conclusions:

  • 13C-GEBT and EGG are viable tools for assessing gastric function in children with EA.
  • A high prevalence of abnormal gastric function exists in this cohort.
  • Despite frequent abnormalities, gastric function did not significantly impact the reported QOL or symptom severity.
Abstract

Keywords:
esophageal atresiagastric functionoctanoic gastric emptying breath testquality of lifesurface electrogastrography

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