Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Virus nuclear import.

Gary R Whittaker1

  • 1Department of Microbiology and Immunology, C5 141 Veterinary Medical Center, Cornell University, Ithaca, NY 14853, USA. grw7@cornell.edu

Advanced Drug Delivery Reviews
|June 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feline health center initiative to track avian flu spread in cats.

American journal of veterinary research·2026
Same author

Rethinking the drivers of coronavirus virulence and pathogenesis; toward an understanding of the dynamic world of mutations, indels, and recombination within the alphacoronaviruses.

mBio·2025
Same author

Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families.

Science advances·2025
Same author

Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics.

Nature·2025
Same author

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6.

PLoS pathogens·2025
Same author

Replication-incompetent VSV-based vaccine elicits protective responses against SARS-CoV-2 and influenza virus.

Science advances·2025
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles

Viruses entering host cell nuclei must navigate complex cellular pathways. Some viruses utilize host import machinery, while others employ unique, virus-driven nuclear import strategies for replication.

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Viruses often replicate within the host cell's nucleus.
  • Nuclear entry requires traversing the cell membrane, cytoplasm, and nuclear envelope.
  • Nuclear pores, the primary entry route, have size limitations that challenge most viruses.

Purpose of the Study:

  • To explore the diverse mechanisms viruses use to enter the host cell nucleus.
  • To differentiate between host-dependent and virus-specific nuclear import pathways.
  • To understand the critical role of trafficking and uncoating in nuclear-replicating viruses.

Main Methods:

  • Literature review of viral nuclear entry mechanisms.
  • Analysis of viral genome trafficking and uncoating processes.

Related Experiment Videos

  • Comparative study of viral strategies versus host cell import machinery.

    • Main Results:

    • Most viruses rely on cellular nuclear import machinery.
    • A subset of viruses utilizes specialized, virus-encoded nuclear import routes.
    • Nuclear entry is contingent upon preceding trafficking and uncoating events for nuclear-replicating viruses.

    Conclusions:

    • Viral nuclear entry is a multifaceted process with diverse strategies.
    • Understanding these pathways is crucial for comprehending viral replication cycles.
    • Virus-encoded mechanisms offer alternative routes to overcome nuclear pore restrictions.