Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Volume controlled apparatus for neonatal tidal liquid ventilation.

Chiara Corno1, Gianfranco B Fiore, Elena Martelli

  • 1Dipartimento di Bioingegneria, Politecnico di Milano, Milan, Italy.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|June 7, 2003
PubMed
Summary

This study introduces a novel liquid breathing system (LBS) for premature infants with respiratory distress syndrome (RDS). The LBS successfully supported newborn pigs for four hours, demonstrating its potential for treating neonatal respiratory failure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to determine when data incompleteness compromises the correct training of data-enhanced mechanical models of haemodialysis? A data quality criterion.

Journal of biomedical informatics·2026
Same author

Surfactant retreatment in very preterm infants with respiratory distress syndrome: an observational cohort study.

Translational pediatrics·2026
Same author

In-Hospital Neonatal Head Injury: A Multicenter Retrospective Cohort Study.

Hospital pediatrics·2026
Same author

Cord blood red cell concentrates for preterm neonate transfusion: Insights from the multicenter BORN trial.

Transfusion·2026
Same author

Nirsevimab Immunization to Prevent Pediatric RSV Hospitalizations.

JAMA pediatrics·2026
Same author

Active treatment vs. expectant management of patent ductus arteriosus in preterm infants: critical analysis of a meta-analysis.

Italian journal of pediatrics·2026

Area of Science:

  • Biomedical Engineering
  • Neonatal Physiology
  • Respiratory Medicine

Background:

  • Conventional gas ventilation is often ineffective for premature infants with respiratory distress syndrome (RDS).
  • Liquid ventilation (LV) using perfluorocarbon (PFC) liquids offers a potential alternative by mitigating air-liquid interface issues in immature lungs.
  • LV can improve pulmonary stability, lung compliance, and recruit atelectatic lung regions.

Purpose of the Study:

  • To develop and evaluate a prototype liquid breathing system (LBS) for neonatal respiratory support.
  • To assess the efficacy and safety of tidal liquid ventilation in an animal model of RDS.

Main Methods:

  • A novel LBS prototype was designed with two subcircuits for ventilation and PFC processing, controlled by a PC.

Related Experiment Videos

  • The ventilation subcircuit utilized peristaltic pumps and a pressure-transducer-based volume measurement system with +/- 0.3 ml accuracy.
  • The refresh subcircuit included filtration, oxygenation, CO2 scavenging, and heat exchange for PFC management.

    • Main Results:

    • The LBS was tested on five newborn mini pigs with induced acquired RDS, successfully supporting them for 4 hours each.
    • Gas exchange was maintained, with mean arterial O2 pressure of 131.4 mm Hg and mean arterial CO2 pressure of 64.8 mm Hg.
    • The system demonstrated accurate volume delivery and effective PFC processing.

    Conclusions:

    • The developed prototype LBS is a viable system for tidal liquid ventilation in neonates.
    • This technology shows promise for supporting premature infants suffering from respiratory distress syndrome.
    • Further research and clinical trials are warranted to validate its use in human neonates.